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KMID : 0379520070230020159
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한국독성학회지
2007 Volume.23 No. 2 p.159 ~ p.164
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Toxicity Screening After Single Dose of a Newly Developed Oral Heparin Derivative in Male Cynomolgus Monkeys
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Kim Choong-Yong
Kim Sang-Kyoon
Woo Young-Ah
Jeong Eun-Ju
Han Su-Cheol
Heo Jeong-Doo
Park Kui-Lea
Byun Young-Ro
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Abstract
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Toxicity screening of a newly developed oral heparin derivative were carried out in 6 male cynomolgus monkeys (Macaca fascicularis), composed of a treatment group and vehicle control group. A newly orally active heparin derivative, developed by Seoul National University, was once given to treatment group at dose of 500 mg/kg. A treatment group did not show any change in body weights, hematological parameters including platelet-related varivables (platelet, PDW, PCT, MPV) and serum biochemical parameters (e.g., AST, ALT, BUN, etc.) for 2 weeks compared with those of vehicle control group. We also confirmed the maximum plasma concentration (Cmax, 1.73 IU/ml) and the time (Tmax, 1 hr) to reach Cmax. The present study will be valuable in the proper interpretation for nonclinical study using cynomolgus monkeys in the development of new drug of heparin derivative.
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KEYWORD
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Cynomolgus monkeys, Oral heparin derivative, Toxicity screening
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